Michelle Dede made her entry into the Nigerian entertainment scene without prior experience, as a co-host for the first season of M-Net/Endemol’s Big Brother Nigeria. The hit reality TV show was the first in Nigeria to be broadcast live across the African continent on DStv. Michelle’s versatility and natural talent saw her go on to host numerous events and product launches for brands including Nokia, Google, Etihad Airways, UBA, Sahara Group, , Clickatell, Lancôme, Maybelline New York, The AMVCA Nominee Show (Viewers Choice Awards) and Afriff (African International Film Festival), to name a few. She was also a host on The Mtn Game Show for three seasons and Ebony Life TV's flagship talk show Moments Nigeria for two years.
Prior to co-hosting Moments Nigeria, in 2014 Michelle auditioned for and was cast as a lead character ‘Tari Gambadia’ in Ebony Life TV's Desperate Housewives Africa; the African adaptation of the original ABC hit TV drama series Desperate Housewives which began her career as an actor. Chosen by Disney's casting directors for the role, her performance as Tari (Susan Meyer in the original US show) once again displayed the inherent talent she possessed despite having no formal acting training.
She has also been advocating against gender based violence and human trafficking, working with ngo’s including Stand to end Rape, Warif_ng (Women at Risk International Foundation), Mirabel Centre Ng and The 300 Project, having also assisted the latter through her diplomatic connections to rescue and repatriate victims of human trafficking from Saudi Arabia to Nigeria.